Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus

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Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus

Nonconvulsive status epilepticus (NCSE) and epilepsia partialis continua (EPC) are common epileptic conditions for which straightforward recommendations based on controlled randomized trials for treatment in therapy refractory courses are lacking. In a large retrospective study on drug efficacy in status epilepticus (SE) we identified the patients treated in our department by searching for the ...

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Intravenous Lacosamide in refractory nonconvulsive status epilepticus

BACKGROUND Many patients present with refractory Status epilepticus (SE) despite multiple anti-epileptic drugs (AEDs). Lacosamide (LCM) was recently approved as an adjunct AED for partial-onset seizures. It has unique mechanism of modulating voltage-gated sodium channels by enhancing their slow inactivation. LCM has demonstrated efficacy in animal models of pharmacoresistant seizures. To date, ...

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Status epilepticus and refractory status epilepticus management.

Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant con...

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Nonconvulsive status epilepticus and coma.

Nonconvulsive status epilepticus (NCSE) in a comatose patient cannot be diagnosed without electroencephalography (EEG). In many advanced coma stages, the EEG exhibits continuous or periodic EEG abnormalities, but their causal role in coma remains unclear in many cases. To date there is no consensus on whether to treat NCSE in a comatose patient in order to improve the outcome or to retract from...

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Lacosamide in absence status epilepticus

Although Lacosamide (LCM) has become a widely used drug in patients with status epilepticus, the role of LCM in patients with idiopathic generalized epilepsy presenting with absence status epilepticus (ASE) is currently unknown. A 57-year-old woman came to be under our observation after experiencing confusion and drowsiness, immediately after waking up. Her family history was unremarkable. Apar...

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ژورنال

عنوان ژورنال: Seizure

سال: 2011

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2011.03.010